Research Lines

Biocircuit Design

Synthetic biology needs to advance towards automated, design methodologies that can warranty predictability.

We develop tools to find in a highly-automated fashion the DNA sequence (biomolecular circuit)  that, once implemented in the host cell, enable it to carry out a predefined task such that the desired behaviour is obtained.

We investigate the role of noise in automated design of biocircuits, aiming also to contribute understanding one fundamental question in biology: how cells can function robustly in highly noisy environments.

Biocircuit Design
Biomolecular network analysis

Biomolecular network analysis

We develop methods to establish mechanism-function relationships in cellular processes: bistability, oscillations, filters, etc.

We investigate the effect of molecular noise in emergent properties related with relevant biological functions

Biomolecular network analysis

We develop methods to establish mechanism-function relationships in cellular processes: bistability, oscillations, filters, etc.

We investigate the effect of molecular noise in emergent properties related with relevant biological functions

Biomolecular network analysis

Advanced Control of Biomolecular Systems

We work on the endogenous (controller inside cells) and exogenous (controller outside cells) control of cell populations, with the aim to drive cells to target phenotypes for applications of interest for synthetic and/or synthetic biology

 Advanced Control of Biomolecular Systems
Dynamic Modeling and Control of Synthetic Pathways

Dynamic Modeling and Control of Synthetic Pathways

Cell factories to produce bio-based compounds/sustainable biomolecules are highly relevant for the bioeconomy.  We are interested in new modeling paradigms of metabolic/regulatory processes with the aim to provide control strategies for synthetic pathways in metabolic engineering.

Dynamic Modeling and Control of Synthetic Pathways

Cell factories to produce bio-based compounds/sustainable biomolecules are highly relevant for the bioeconomy.  We are interested in new modeling paradigms of metabolic/regulatory processes with the aim to provide control strategies for synthetic pathways in metabolic engineering.

Dynamic Modeling and Control of Synthetic Pathways